Endocrine Abstracts

Liver fatty acid-binding protein (LFABP) is a 14 kDa cytoplasmatic protein found in hepatocytes and enterocytes of the small intestine. It binds long chain fatty acids (LCFA) and other hydrophobic ligands and is thought to play an important role in intracellular LCFA transport.We investigated the regulation of LFABP gene expression by thyroid hormone (T3) and peroxisome proliferator-activated receptor alpha (PPARalpha) ligand clofibric acid.<p class=...

The FAD-dependent, mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) is essential for the transport of reducing equivalents derived from glycolysis (or in sperm fructolysis) into the mitochondrial compartment for the synthesis of ATP. It has been shown that multiple (three) promoters of the mGPDH exist so that the expression is regulated in a tissue-restricted manner. Promoter A is expressed in brain, brown adipose tissue and pancreas, promoter B is ubiquitous and promo...